Mesonephric Carcinoma of the Ovary: A Report of Two Cases

Mesonephric carcinomas of the female genital tract are rare tumors, mainly occurring in the cervix and exceptionally in the uterine corpus. There seems to be a paradigm that the only mesonephric neoplasms arising from the upper zone of the Wolffian system are FATWOs. Indeed, no cases of mesonephric carcinoma of the ovary have been reported in the recent literature. Herein, we describe two cases of ovarian carcinoma with histologic features consistent with mesonephric adenocarcinoma. In both cases, the initial diagnosis of well-differentiated endometrioid adenocarcinoma was withdrawn because of other coexistent growth patterns, and the presence of admixed mesonephric-type structures. The mesonephric identity of the tumors was supported immunohistochemically, in particular by their uniform negativity for ER and PR, and strong reactivity for CD10.